Phase Genomics Blog

Bringing you the latest in Hi-C genomics, metagenomics, and other scientific musings.

It's Phase Genomics mission to bring you tools that make it easier to answer hard questions and make more discoveries. Part of that mission means sharing our knowledge, tips-and-tricks, successes and failures, and other thoughts with the community, as well as the experiences of other researchers using our tools to do great work. This blog covers the use of Hi-C and other chromatin conformation capture techniques for both genomics and metagenomics, as well as other new developments and trends in the genomics field.


October 18, 2017

Hundreds of Genomes Isolated from Single Fecal Sample with the ProxiMeta Hi-C Metagenome Deconvolution Kit

  Phase Genomics recently launched its ProxiMeta™ Hi-C metagenome deconvolution kit+software product, enabling researchers to bring this powerful technology (previously only available through the ProxiMeta service) into their own labs. A new paper posted to biorxiv describes the results of employing ProxiMeta technology to deconvolute a human gut microbiome sample.   In the paper, ProxiMeta... Read more »


September 1, 2017

Orphan Crop Gains Reference Genome with Proximo Hi-C

Amaranth genome assembly brought to the chromosome-scale using Phase Genomics’ Proximo Hi-C technology.    “Orphan crops” are growing in popularity because they have the potential to feed the world’s expanding population.  You may have heard of orphan crops like quinoa or spelt, but have you heard of amaranth?  The amaranth genus (Amaranthus) is a hearty... Read more »


August 11, 2017

Threespine Stickleback Genome Upgraded Using Phase Genomics’ Proximo™ Hi-C Technology

Threespine stickleback

Proximo Hi-C genome scaffolding not only improved the well-studied threespine stickleback assembly, but also found structural differences that would have otherwise been missed.    This week researchers from the University of Bern and the University of Georgia released a new high-quality reference threespine stickleback genome. The results of this project, a joint collaboration between Dr.... Read more »


July 7, 2017

Spotlight on Hi-C in Science: New Technologies Boost Genome Quality

Science writer, Elizabeth Pennisi, outlines available genomics technologies that are helping researchers improve genome assemblies with a focus on Hi-C’s ability to bring genome assembly to the chromosome-scale. This article, by Elizabeth Pennisi, focuses on how new technologies are making genome quality much better.  Long-reads, optical maps, and Hi-C data are being synergistically applied to... Read more »


April 27, 2017

Hi-C Used to Assemble Extremely Large, Difficult Barley Genome

Barley is the 4th most cultivated plant in the world and has been a reliable food source for over 10,000 years. Genome Web reports on the exceptional state of the genome assembly and how researchers used Hi-C technology to tackle this extremely complex genome.   The barley genome, like many other grains, is notorious for... Read more »


March 29, 2017

Spotlight on Hi-C in The Atlantic: The Game-Changing Technique That Cracked the Zika-Mosquito Genome

One of the most prolific science writers, Ed Yong, profiles how Hi-C sequencing technologies can make genome assembly easier and more cost-effective than ever before.  Science writer Ed Yong covers the narrative on the researchers’ tackling the disease carrying Aedes aegypti genome, and how Hi-C “knitted” the genome from 36,000 pieces into complete and contiguous... Read more »


March 6, 2017

Papadum’s Recipe for an Outstanding, Chromosome-Scale Genome

Meet Papadum the Goat! Papadum is a descendent from a rare population of goats that used to inhabit the San Clemente Island, and notably, Papadum also now holds the world record for the most contiguous non-model mammalian genome.  The recipe for a his amazing de novo genome assembly? Long reads, optical mapping, and Proximo Hi-C genome... Read more »