Phase Genomics Blog

Bringing you the latest in Hi-C genomics, metagenomics, and other scientific musings.

Phase Genomics' mission is to bring you tools that make it easier to answer hard questions and make more discoveries. Part of that mission means sharing our knowledge, tips-and-tricks, successes and failures, and other thoughts with the community, as well as the experiences of other researchers using our tools to do great work. This blog covers the use of Hi-C and other chromatin conformation capture techniques for both genomics and metagenomics, as well as other new developments and trends in the genomics field.


August 8, 2018

Hi-C solves the problem of linking plasmids to hosts in microbiome samples

Learn how Hi-C can be used to assign plasmids to hosts in any microbial sample. Plasmids are an important part of microbial biology, able to confer virulence traits or resistance to antibiotic drugs, and can be readily shared among bacterial cells through cell-cell conjugation or other means.


August 1, 2018

Lil BUB Aids in Discovery of New Bacteria

Published author, talk show host, movie star, musician, and philanthropist—Lil BUB has now also helped to discover novel microbial life living in her gut in collaboration with AnimalBiome, KittyBiome, and Phase Genomics. Enter to sequence your cat’s microbiome in our #Meowcrobiome twitter raffle!


April 19, 2018

Phase Genomics and Pacific Biosciences Co-Developing new Genome Assembly Phasing Software

Phase Genomics and Pacific Biosciences logos

“FALCON-Phase” – an algorithm for producing diploid genomes.   Phase Genomics has entered into a co-development agreement with Pacific Biosciences to develop FALCON-Phase, a software module that combines Hi-C and PacBio® highly-accurate, long read sequencing data to produce fully-phased diploid genome assemblies. The software will be released later this spring. FALCON-Phase augments PacBio Single Molecule,... Read more »


March 28, 2018

A sweet new genome for the black raspberry using Proximo™ Hi-C

Black raspberries

The Black Raspberry, known for its sweetness and health benefits studied further to reveal its chromosome-scale genome. What is a black raspberry you may ask? Jams, preserves, pies, and liqueur are just a few of the delicious products made with black raspberry. The black raspberry offers much more beyond its exquisite flavors. For instance, did... Read more »


March 15, 2018

New Video: From Contigs to Chromosomes

Phase Genomics CEO and Founder Ivan Liachko, Ph.D. offers an inside look at our ProxiMeta™ Hi-C and Proximo™ Hi-C technology. He explains in this 40 minute presentation how Hi-C is revolutionizing genome and metagenome assembly. Watch "From Contigs to Chromosomes" now and reach out to http://phasegenomics.com/contact-us/ with any questions.


March 1, 2018

Uncovering the microbiome: What will you do with metagenomics?

In this Nature Microbiology blog post, Mick Watson shares his journey into the depths of the rumen microbiome. Read more here to learn how Phase Genomics ProxiMeta Hi-C Metagenomic Deconvolution techniques are helping investigators advance their metagenomic research in complex samples. This study successfully assembled 913 genomes and will help to improve our understanding of... Read more »


October 18, 2017

Hundreds of Genomes Isolated from Single Fecal Sample with Hi-C Kit

  Phase Genomics recently launched its ProxiMeta™ Hi-C metagenome deconvolution kit + software product, enabling researchers to bring this powerful technology (previously only available through the ProxiMeta service) into their own labs. A new paper posted to biorxiv describes the results of employing ProxiMeta technology to deconvolute a human gut microbiome sample.   In the... Read more »


September 1, 2017

Orphan Crop Gains Reference Genome with Proximo Hi-C

Amaranth genome assembly brought to the chromosome-scale using Phase Genomics’ Proximo Hi-C technology.    “Orphan crops” are growing in popularity because they have the potential to feed the world’s expanding population.  You may have heard of orphan crops like quinoa or spelt, but have you heard of amaranth?  The amaranth genus (Amaranthus) is a hearty... Read more »


August 11, 2017

Threespine Stickleback Genome Upgraded Using Proximo™ Hi-C

Threespine stickleback

Proximo Hi-C genome scaffolding not only improved the well-studied threespine stickleback assembly, but also found structural differences that would have otherwise been missed.    This week researchers from the University of Bern and the University of Georgia released a new high-quality reference threespine stickleback genome. The results of this project, a joint collaboration between Dr.... Read more »


July 7, 2017

Spotlight on Hi-C in Science: New Technologies Boost Genome Quality

Science writer, Elizabeth Pennisi, outlines available genomics technologies that are helping researchers improve genome assemblies with a focus on Hi-C’s ability to bring genome assembly to the chromosome-scale. This article, by Elizabeth Pennisi, focuses on how new technologies are making genome quality much better.  Long-reads, optical maps, and Hi-C data are being synergistically applied to... Read more »