Massively parallel shotgun sequencing is only uncovering a part of the story. Unlock an added dimension with our proximity ligation (Hi-C) chemistry and computational tools, to help deliver on the promise of genomics.
Deconvolute complex metagenomic samples; discover new species, strains and genes; attribute mobile genetic elements to their hosts; study the human microbiome, infectious disease, antibiotic resistance and gene function.
Construct high-quality, chromosome-scale reference genomes; resolve haplotypes and polyploidy; compare and study gene structure, function and interactions; understand biology and evolution to conserve and protect biodiversity.
Assemble fully phased de novo genomes; detect genetic and epigenetic variation; characterize translocations, copy number variation and TADs; analyze genome and chromatin architecture; study cancer; advance precision genomics.
Our proximity ligation (Hi-C) chemistry and computational tools enable you to generate direct, quantitative evidence of the spatial relationships between DNA sequences in vivo. This “ultra long-range” information adds another dimension to shotgun sequence data. It enables deeper insights into the architecture, variation, function and complexity of genomes, epigenomes, microbiomes and metagenomes.
“The thing that was fun was that [the Phase Genomics team] were definitely personally invested in our research. It wasn’t just a payment for service thing. They were genuinely interested in our results. It’s fun to work with people who are interested in the results.”
Prof. Dr. Catherine (Katie) Peichel
Head: Division Evolutionary Ecology, University of Bern
“The direct association of mobile genetic elements with their microbial hosts in complex populations is one of the last remaining technological challenges in the microbiome space. Proximity ligation is an elegant way to overcome this obstacle and presents a promising key technology in the study of bacteriophage and antibiotic resistance biology within a microbial context.”
Prof. Paul Plummer
Iowa State University and Executive Director of the Institute for Antimicrobial Resistance Research and Education
“The level of genome completeness and contiguity yielded by this technology has transformed how we view genome projects and has enabled us to ask new biological questions.”
Prof. Jeff Maughan
Department of Plant & Wildlife Sciences, Brigham-Young University
Curious to learn how you can integrate Hi-C in your project?