Phase Genomics Blog

Bringing you the latest in Hi-C genomics, metagenomics, and other scientific musings.

Phase Genomics' mission is to bring you tools that make it easier to answer hard questions and make more discoveries. Part of that mission means sharing our knowledge, tips-and-tricks, successes and failures, and other thoughts with the community, as well as the experiences of other researchers using our tools to do great work. This blog covers the use of Hi-C and other chromatin conformation capture techniques for both genomics and metagenomics, as well as other new developments and trends in the genomics field.


May 27, 2021

Better together: long-range and long-read DNA sequencing methods, combined, reach record heights in microbiome discovery

Microbiome plate and Phase Genomics logo. Reads "Breaking records in microbiome discovery"

  Click here for an updated blog post.   Since its debut, next-generation sequencing has not rested on its laurels. Improved sequencing platforms have reduced error and lengthened reads into the tens of thousands of bases. The debut of long-range sequencing methods that are based on proximity ligation (aka Hi-C) has brought a new order-of-magnitude... Read more »


April 29, 2021

New genome assembly method makes fruitful advances in genomic technology

  A collaboration between Phase Genomics and Pacific Biosciences of California is bringing about the next generation of genome assembly technology. A newly published software tool, FALCON-Phase, combines genomic proximity ligation methods developed by Phase Genomics™, with the high accuracy, long-read sequencing data from PacBio®, enabling researchers to create haplotype-resolved genome sequences on a chromosomal... Read more »


March 17, 2021

Startup Stories: Navigating the Ins and Outs of Incubators and Accelerators

Insights from the Trenches with Genomics Startup Founders   In the first Genome Startup Day event of 2021, we highlighted one of the most critical decisions facing early-stage founders: whether or not to enter an accelerator or incubator. Three genomics startup founders from across the US shared how their unique experiences helped shape their company’s... Read more »


March 3, 2021

Founders: Why You Should Consider a Chief Janitorial Officer

  Insights for biotech founders from a leading voice in genomics commercialization   What’s in a fancy startup C-suite title? The answer from luminaries is: “nothing if the startup fails.” In the first Genome Startup Day of 2021, Phase Genomics’ Founder and CEO Ivan Liachko, PhD, sat down with Mostafa Ronaghi, PhD, Senior VP for... Read more »


February 25, 2021

Phase Genomics Developing Cost-Effective Genomic Tools to Track and Understand Crop Disease with New Funding

  The impact of fungal rust pathogens is measured in tens of thousands of acres of lost crops annually and an increasingly vulnerable supply chain. An outbreak of oat crown rust devastated yields in South Dakota and Minnesota, wiping out as much as 50% of the crop in 2014 alone.     Current surveillance rust collections... Read more »


January 4, 2021

Year in Review: New Products, Projects, & Partnerships Amidst a Pandemic

  Greetings from, mercifully, the beginning days of 2021. As the world reels from Covid-19, all of our personal and professional lives have all been turned upside down. Despite this challenging environment, Phase Genomics has celebrated some big wins in 2020, amidst a tumultuous year. This year’s successes include releasing a dedicated Proximo Hi-C Kit... Read more »


October 29, 2020

Phase Genomics and QIAGEN Partner to Bring Hi-C Epigenetics Solutions to U.S. Market

In the last few years, Hi-C technology has grown in popularity within the epigenetics community. The chief application this proprietary method is to measure the three-dimensional architecture of genomes to better understand complex nuclear dynamics. Being a leader in this space, we at Phase Genomics seek to maximize the commercial footprint of our technology. As interest in this... Read more »


July 16, 2020

Unlocking New Frontiers in our Understanding of Human Disease through Deep Learning and Three-Dimensional Genomics

  By Ivan Liachko, Ph.D – Founder & CEO, Phase Genomics   As we enter the era of personalized medicine, novel genomic technologies are enabling a much deeper understanding of the biology of individual people. Such knowledge improves our ability to detect and diagnose diseases, offering personalized treatments that leverage each person’s unique genetic makeup... Read more »


February 10, 2020

Breaking the Mold: New Tech Sheds Light on 5 Mysteries of the Fungal World

  This month Phase Genomics is celebrating #FungusFebruary by highlighting some of the unique capabilities of our Hi-C technology to solve age-old mysteries in the world of fungal genetics and deliver new potential for researchers to understand fungi, all while helping solve global crop crises and develop new groundbreaking pharmaceuticals. While we wield the power... Read more »


January 9, 2020

2019: A Year in Review with Phase Genomics

  From scaling up the ProxiMeta Platform to publishing numerous Hi-C papers, Phase Genomics has had a year filled with new products, new discoveries, and new applications. Proximity ligation technology is continuing to fuel genomic and metagenomic research. Here is a brief recap of newsworthy items from 2019.     Metagenomics Publications MAY 30, 2019... Read more »